PubMed COVID-19 Clinical Care
23921 - 23930 of 44979 results found
Design of a bifunctional pan-sarbecovirus entry inhibitor targeting the cell receptor and viral fusion protein
Description
Development of highly effective antivirals that are robust to viral evolution is a practical strategy for combating the continuously evolved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inspired by viral multistep entry process, we
An Ultrasensitive SPR biosensor for RNA detection based on robust GeP5 nanosheets
Description
Ultrasensitive and rapid detection of biomarkers is among the upmost priorities in promoting healthcare advancements. Improved sensitivity of photonic sensors based on two-dimensional (2D) materials have brought exciting prospects for achieving real
High plasma soluble CLEC-2 level predicts oxygen therapy requirement in patients with COVID-19
Description
Predicting the clinical course and allocating limited medical resources appropriately is crucial during the COVID-19 pandemic. Platelets are involved in microthrombosis, a critical pathogenesis of COVID-19; however, the role of soluble CLEC-2 (sCLEC
Addressing vaccine concerns through the spectrum of vaccine acceptance
Description
CONCLUSION: Factors which determine and differentiate vaccine concerns among healthcare professionals in a low-income context show that rational concerns far outweigh non-sensical and conspiratorial views. The findings will act as a useful input into
The Effect of SARS-Cov2 Infection on The Spermogram: A Prospective Study
Description
CONCLUSION: SARS-CoV-2 affected semen parameters in patients admitted because of COVID-19, in the short term. It is expected that this will improve with time.
Closing the Evidence Gap of Cash Transfer for Tuberculosis-Affected Households Comment on "Does Direct Benefit Transfer Improve Outcomes Among People With Tuberculosis? - A Mixed-Methods Study on the Need for a Review of the Cash Transfer Policy in India"
Description
Achieving the targets of eliminating tuberculosis (TB) requires a combination of biomedical, epidemiological, and social approaches. Having hitted by the coronavirus disease 2019 (COVID-19) pandemic which diminishes the financial capacity of TB
Graphical Learning and Causal Inference for Drug Repurposing
Description
Gene expression profiles that connect drug perturbations, disease gene expression signatures, and clinical data are important for discovering potential drug repurposing indications. However, the current approach to gene expression reversal has
The Fentanyl System Shock - Are There Lessons to Learn From the COVID-19 System Shock Framework? Comment on "The COVID-19 System Shock Framework: Capturing Health System Innovation During the COVID-19 Pandemic"
Description
The Sydney Children's Hospitals Network (SCHN) addressed the challenges of the COVID-19 pandemic by implementing innovative changes which made their health system resilient and responsive. For other healthcare systems, there are important takeaways
Biophysical principles predict fitness of SARS-CoV-2 variants
Description
SARS-CoV-2 employs its spike protein's receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. However, understanding