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PubMed COVID-19 Clinical Care

1761 - 1770 of 44979 results found

Structural Relationships to Efficacy for Prazole-Derived Antivirals

Date
Wednesday, March 06, 2024 - 4:00 AM
Description
Here, an in vitro characterization of a family of prazole derivatives that covalently bind to the C73 site on Tsg101 and assay their ability to inhibit viral particle production is presented. Structurally, increased steric bulk on the 4-pyridyl of

In Silico Evaluation of NO-Sartans against SARS-CoV-2

Date
Wednesday, March 06, 2024 - 4:00 AM
Description
CONCLUSION: Based on our in silico studies, CLC-1280 (a Valsartan dinitrate) has the potential to be considered as an inhibitor of the SARS-CoV-2 virus. However, further in vitro and in vivo evaluations are necessary for the drug development process.